Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma: Biomarker of squamous cell carcinoma

Choudhry, Nakhshab and Sarmad, Sana and Waheed, Noor ul Ain and Gondal, Aamir Jamal (2019) Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma: Biomarker of squamous cell carcinoma. Pakistan Journal of Medical Sciences, 35 (1). pp. 252-256. ISSN 1682-024X

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Abstract

Objective: To estimate the serum levels of matrix metalloproteinases in oral squamous cell carcinoma patients and in healthy subjects.

Methods: In this observational study, biopsy diagnosed oral squamous cell carcinoma patients (n= 38) were recruited from Mayo Hospital, Lahore during 2016 to 2017. Age and gender matched Controls (n= 38) were also included. Venous blood sample of each participant was drawn, serum separated and the levels of matrix metalloproteinases were measured by multiplex ELISA.

Results: Serum levels of MMP-1, -8, -10, -12 and -13 in OSCC patients showed statistically significant increase as compared to control group (p < 0.01). The MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80% and 78.9%, respectively for a cut-off value of 16.13 pg/ml.

Conclusions: MMP-12 has been found to have significant sensitivity and specificity to qualify as a diagnostic biomarker.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 27 Apr 2023 05:57
Last Modified: 07 Jun 2024 09:57
URI: http://library.2pressrelease.co.in/id/eprint/1041

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