Role of Different Ovulation Induction Protocols in Follicular Growth, Estradiol and Pregnancy Rates for Women with Unexplained Infertility and Polycystic Ovary Syndrome Undergoing Intrauterine Insemination

Introduction: The study aimed to study the effects of ovulation induction programs on the number of pre-ovulatory dominant follicles and endometrial thickness, their effects on pre-ovulatory estradiol 2 levels, and to determine the favored ovulation induction protocol to attain better pregnancy results in polycystic ovary syndrome and unexplained infertility women.

Materials and Methods: Twenty unexplained infertile and thirty polycystic ovary syndrome women subjected to ovulation induction/intrauterine insemination were enrolled in this study. First ovulation induction protocol involved clomiphene citrate only, the second involved Gonal-f only, and the third involved combination of clomiphene citrate and Gonal-f. Immediately before triggering of ovulation, follicular parameters, endometrial thickness, and estradiol 2 mean levels were measured.

Results: Only two (4%) subjected to combination of clomiphene citrate and Gonal-f became pregnant. Combination of clomid and Gonal-f yielded better pre-ovulatory endometrial thickness and higher pre-ovulatory estradiol 2 mean levels for all cases.

Conclusions: Combination of clomid and Gonal-f attained better results.