Expressions and clinical significance of serum bone Gla-protein, bone alkaline phosphatase and C-terminal telopeptide of type I collagen in bone metabolism of patients with osteoporosis

Objective: This study aimed to evaluate the expressions and clinical significance of bone Gla-protein (BGP), bone alkaline phosphatase (B-ALP) and C-terminal telopeptide of type I collagen (CTX) in patients with osteoporosis (OP), and to provide evidence for developing individualized treatment plans.

Methods: Seventy-two OP patients in our hospital were selected as an OP group, and another 72 healthy subjects were used as a control group. Their BGP, B-ALP and CTX levels as well as bone mineral density (BMD) values were measured. The correlations between BGP, B-ALP and CTX levels and BMD values were determined.

Results: The BGP level of the OP group [(5.61±5.52) ng/ml] was significantly higher than that of the control group (P<0.05), but the levels of B-ALP and CTX did not differ significantly (P>0.05). The BMD values of femoral neck and Ward’s triangle in the OP group were negatively correlated with the B-ALP levels (P<0.05). For women OP patients, the BMD values of femoral neck and Ward’s triangle were also negatively correlated with the B-ALP levels (P<0.05). The BMD of femoral neck in the control group was negatively correlated with the CTX level (P<0.05).

Conclusion: Determining BGP, B-ALP and CTX levels can evaluate the bone metabolism degree, which provides evidence for clinical typing of OP and developing treatment strategies.