A glance at the application of CRISPR/Cas9 gene-editing technology in cardiovascular diseases

Roshanravan, Neda and Tutunchi, Helda and Najafipour, Farzad and Dastouri, Mohammadreza and Ghaffari, Samad and Jebeli, Alireza (2022) A glance at the application of CRISPR/Cas9 gene-editing technology in cardiovascular diseases. Journal of Cardiovascular and Thoracic Research, 14 (2). pp. 77-83. ISSN 2008-5117

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Abstract

Cardiovascular diseases (CVDs) remain major causes of global mortality in the world. Genetic approaches have succeeded in discovery of the molecular basis of an increasing number of cardiac diseases. Genome editing strategies are one of the most effective methods for assisting therapeutic approaches. Potential therapeutic methods of correcting disease-causing mutations or of knocking out specific genes as approaches for the prevention of CVDs have gained substantial attention using genome editing techniques. Recently, the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system has become the most widely used genome-editing technology in molecular biology due to its benefits such as simple design, high efficiency, good repeatability, short-cycle, and costeffectiveness. In the present review, we discuss on the possibilities of applying the CRISPR/Cas9 genome editing tool in the CVDs.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 10 May 2023 06:19
Last Modified: 17 Oct 2024 04:38
URI: http://library.2pressrelease.co.in/id/eprint/1143

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