Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters

Organic acids and their derivatives like butyl stearate have recently shown antisickling activity. Some none aromatic esters were synthetized and tested for their antisickling activity using Emmel test. On 21 esters tested only three showed no antisickling activity. Butyl palmitate, propyl palmitate, butyl stearate, propyl stearate and methyl nonadecanoate showed interesting antisickling activity with a normalization rate higher than 70%.