Neuronal Migration During Development of the Cerebellum

Rahimi-Balaei, Maryam and Bergen, Hugo and Kong, Jiming and Marzban, Hassan (2018) Neuronal Migration During Development of the Cerebellum. Frontiers in Cellular Neuroscience, 12. ISSN 1662-5102

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Abstract

Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in the neuronal migration may result in a neurological disorder. The cerebellum, as a part of the CNS, plays a pivotal role in motor coordination and non-motor functions such as emotion, cognition and language. The excitatory and inhibitory neurons within the cerebellum originate from different distinct germinal zones and migrate through complex routes to assemble in a well-defined neuronal organization in the cerebellar cortex and nuclei. In this review article, the neuronal migration modes and pathways from germinal zones to the final position in the cerebellar cortex and nuclei will be described. The cellular and molecular mechanisms involved in cerebellar neuronal migration during development will also be reviewed. Finally, some diseases and animal models associated with defects in neuronal migration will be presented.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 29 May 2023 04:48
Last Modified: 05 Jun 2024 09:50
URI: http://library.2pressrelease.co.in/id/eprint/1343

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