Prevalence and Diversity of Hepatitis Virus Markers among Patients with Acute Febrile Jaundice in Chad

Yandai, Fissou Henry and Traore, Kuan Abdoulaye and Moussa, Ali Mahamat and Ouoba, Bruno Lalidia and Ouoba, Jean Bienvenue and Bolti, Mahamat Ali and Abakar, Mahamat Fayiz and Hota, Mathieu and Gamougam, Kadidja and Nadlao, Bessimbaye and Uwimbabazi, Jean-Claude and Tao, Nadji Emmanuel and Ngandolo, Bongo Nare and Roques, Pierre and Barro, Nicolas (2021) Prevalence and Diversity of Hepatitis Virus Markers among Patients with Acute Febrile Jaundice in Chad. Microbiology Research, 12 (4). pp. 878-887. ISSN 2036-7481

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Abstract

Only a minority of the patients with acute febrile jaundice evaluated through the Yellow Fever surveillance program were found positive for antibodies against Yellow Fever Virus (YFV). In order to characterize patients with acute febrile jaundice negative for YFV, we collected 255 sera between January to December 2019. We screened for HBV antigens, and antibodies against HCV and HEV. The seroprevalences observed were 10.6% (27/255) for HBV, 2% (5/255) for HCV, 17.3% (44/255) for HEV IgG, 4.3% (11/255) for HEV IgM, and 12.5% (32/255) for both IgG and IgM HEV. Prevalence of HEV was significantly higher in females than males (p < 0.01). HEV IgG prevalence was highest in those 20–29 years old, but the highest incidence rate (IgM positive) was in children 0–9 years old. Exposure to HEV was higher in the Sahelian zone (55.8%, 95%CI: 40.97–70.66) than in the Sudanese zone (30.2%, 95% CI: 24.01–36.37, p = 0.003). The high prevalence rates and hepatitis virus diversity underline the challenge of routine clinical diagnosis in Chad’s Yellow Fever surveillance program.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 16 Jun 2023 05:14
Last Modified: 26 Mar 2024 03:53
URI: http://library.2pressrelease.co.in/id/eprint/1555

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