Evaluation of Acute, Sub-Chronic Oral Toxicity Studies and Anti-Inflammatory Activity of Blumea mollis in Experimental Animals

Kumar, Santosh and Chandra, Phool and Mani, Munesh (2021) Evaluation of Acute, Sub-Chronic Oral Toxicity Studies and Anti-Inflammatory Activity of Blumea mollis in Experimental Animals. Journal of Pharmaceutical Research International, 33 (60B). pp. 3130-3136. ISSN 2456-9119

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Abstract

Objective: The goal of this study was to test the ethanol extract of the aerial part of the Blumea mollis (Asteraceae) for acute and sub-chronic toxicity as well as anti-inflammatory efficacy.

Methods: The shade dried aerial part of Blumea mollis (0.5 kg) was powdered and extracted with ethanol. Ethanol extracts was used for these studies. Acute oral and sub-chronic toxicity studies were performed as per OECD guidelines. The anti-inflammatory effect was studied by carrageenan-induced paw edema model in rats at dose levels 100, 200, and 400 mg/kg, orally.

Results: The results indicate that ethanol extract of Blumea mollis was found to be safe at the dose of 2000mg/kg. The EBM 100, 200 and 400 mg/kg exhibited significant inhibition (p<0.001) of increase in paw edema in rats.

Conclusion: The results of the experimental study confirmed that ethanol extract of Blumea mollis is devoid of toxicity and possesses significant anti-inflammatory activity.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 08 Mar 2023 09:52
Last Modified: 22 May 2024 09:08
URI: http://library.2pressrelease.co.in/id/eprint/313

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