Long-Term Impact of Social Isolation and Molecular Underpinnings

Arzate-Mejía, Rodrigo G. and Lottenbach, Zuzanna and Schindler, Vincent and Jawaid, Ali and Mansuy, Isabelle M. (2020) Long-Term Impact of Social Isolation and Molecular Underpinnings. Frontiers in Genetics, 11. ISSN 1664-8021

[thumbnail of pubmed-zip/versions/1/package-entries/fgene-11-589621/fgene-11-589621.pdf] Text
pubmed-zip/versions/1/package-entries/fgene-11-589621/fgene-11-589621.pdf - Published Version

Download (251kB)

Abstract

Prolonged periods of social isolation can have detrimental effects on the physiology and behavior of exposed individuals in humans and animal models. This involves complex molecular mechanisms across tissues in the body which remain partly identified. This review discusses the biology of social isolation and describes the acute and lasting effects of prolonged periods of social isolation with a focus on the molecular events leading to behavioral alterations. We highlight the role of epigenetic mechanisms and non-coding RNA in the control of gene expression as a response to social isolation, and the consequences for behavior. Considering the use of strict quarantine during epidemics, like currently with COVID-19, we provide a cautionary tale on the indiscriminate implementation of such form of social isolation and its potential damaging and lasting effects in mental health.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 25 Jan 2023 09:17
Last Modified: 16 Jul 2024 07:40
URI: http://library.2pressrelease.co.in/id/eprint/335

Actions (login required)

View Item
View Item