The Value of Mouse Models of Rare Diseases: A Spanish Experience

Murillo-Cuesta, Silvia and Artuch, Rafael and Asensio, Fernando and de la Villa, Pedro and Dierssen, Mara and Enríquez, Jose Antonio and Fillat, Cristina and Fourcade, Stéphane and Ibáñez, Borja and Montoliu, Lluis and Oliver, Eduardo and Pujol, Aurora and Salido, Eduardo and Vallejo, Mario and Varela-Nieto, Isabel (2020) The Value of Mouse Models of Rare Diseases: A Spanish Experience. Frontiers in Genetics, 11. ISSN 1664-8021

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Abstract

Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and greatly contribute to accelerate the development of new therapeutic options for rare diseases. Despite this, the use of experimental animals remains controversial. The combination of respectful management, ethical laws and transparency regarding animal experimentation contributes to improve society’s opinion about biomedical research and positively impacts on research quality, which eventually also benefits patients. Here we present examples of current advances in preclinical research in rare diseases using mouse models, together with our perspective on future directions and challenges.

Item Type: Article
Subjects: Open Archive Press > Medical Science
Depositing User: Unnamed user with email support@openarchivepress.com
Date Deposited: 24 Jan 2023 06:29
Last Modified: 28 Mar 2024 04:04
URI: http://library.2pressrelease.co.in/id/eprint/341

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