Le Clerc, Sigrid and Limou, Sophie and Zagury, Jean-François (2019) Large-Scale “OMICS” Studies to Explore the Physiopatholgy of HIV-1 Infection. Frontiers in Genetics, 10. ISSN 1664-8021
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Abstract
In this review, we present the main large-scale experimental studies that have been performed in the HIV/AIDS field. These “omics” studies are based on several technologies including genotyping, RNA interference, and transcriptome or epigenome analysis. Due to the direct connection with disease evolution, there has been a large focus on genotyping cohorts of well-characterized patients through genome-wide association studies (GWASs), but there have also been several invitro studies such as small interfering RNA (siRNA) interference or transcriptome analyses of HIV-1–infected cells. After describing the major results obtained with these omics technologies—including some with a high relevance for HIV-1 treatment—we discuss the next steps that the community needs to embrace in order to derive new actionable therapeutic or diagnostic targets. Only integrative approaches that combine all big data results and consider their complex interactions will allow us to capture the global picture of HIV molecular pathogenesis. This novel challenge will require large collaborative efforts and represents a huge open field for innovative bioinformatics approaches.
Item Type: | Article |
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Subjects: | Open Archive Press > Medical Science |
Depositing User: | Unnamed user with email support@openarchivepress.com |
Date Deposited: | 06 Feb 2023 06:28 |
Last Modified: | 02 Oct 2024 08:21 |
URI: | http://library.2pressrelease.co.in/id/eprint/374 |