THE LEVELS OF MARKERS OF COLLAGEN METABOLISM IN CHRONIC PROSTATITIS

We have studied the levels of markers of collagen exchange 280 in infertile and fertile patients with chronic prostatitis. All patients were divided into 2 groups: group 1 - sterile (140 persons) and group 2 - fertile patients matched for age (140 people). The mean age of patients was 34 [22; 43]. The median disease duration was 6 [2; 4] years. The control group consisted of 50 healthy men of reproductive age. In the serum samples was carried out determining the level of transforming growth factor-β1 (TGF-β1), the level of C-terminal telopeptide of type I collagen (CTP) and carboxyterminal of propeptide of procollagen I (CAT). Revealed the effects of the fibrosis processes, as well as excess formation and degradation of collagen type 1 on the development of infertility in patients with chronic prostatitis. This conclusion was also confirmed by the results of the correlation analysis revealed the relationship between the presence of infertility and the level of TGF-β1 (r=0,61 p<0.001), CAT (r=0,64 p<0.001), CTP (r=0,31 p=0,021).